Buy Nucleofill Skin Booster Online | Promoitalia Polynucleotide Range for UK & EU Clinics
Nucleofill is a CE-certified polynucleotide (PN) skin booster range manufactured by Promoitalia, an Italian leader in regenerative medicine and medical aesthetics. At ProAestheticSupply.eu, you can buy the full Nucleofill range — including Soft Plus, Medium, Strong, 25, and Eyes — with fast delivery across both the UK and EU, verified authenticity, and B2B pricing for licensed clinics.
Formulated from highly purified fish DNA fragments that closely resemble human DNA, Nucleofill works through a three-way mechanism: activating fibroblast receptors to stimulate type I collagen and elastin production, providing antioxidant defence against free radicals and environmental damage, and attracting water molecules for deep, prolonged hydration. Unlike hyaluronic acid boosters, which primarily hydrate temporarily, Nucleofill’s polynucleotide content delivers true bio-revitalization — improving skin firmness, elasticity, and texture from within, with results building progressively over a course of 2–4 sessions spaced a few weeks apart.
Nucleofill spans strength levels to suit different skin concerns and patient ages — from Soft Plus for surface-level hydration through to Strong and 25 for advanced bio-stimulation, plus a dedicated Eyes formulation. Pair it with our dermal fillers for complete facial rejuvenation, or browse the wider skin boosters category. Products supplied to UK clinics meet UK MHRA-recognised standards, while EU orders carry CE marking under EU MDR. Nucleofill is intended strictly for use by licensed healthcare and aesthetic professionals.
Shop the Nucleofill range below — Soft Plus, Medium, Strong, 25, and Eyes — each formulated to a specific polynucleotide concentration for mild to advanced skin regeneration. Shipped to clinics across the UK and EU. Browse our full skin boosters range for more options.
Buy Nucleofill
Buy Nucleofill
Buy Nucleofill
Buy Nucleofill
Buy Nucleofill
A Complete Buying Guide to Nucleofill
Nucleofill’s polynucleotides work through fibroblast activation — transforming fibroblasts into myofibroblasts that drive new type I collagen and elastin production, causing the skin to gradually thicken and lift. This is combined with antioxidant activity that removes free radicals, and a deep hydration effect from the PN molecules attracting and retaining water in the dermis.
What’s the difference between the Nucleofill strengths?
Nucleofill Soft Plus is designed for surface-level hydration and early fine lines, suited to younger patients or preventative protocols. Nucleofill Medium offers a balanced regeneration formula for mild to moderate skin concerns. Nucleofill Strong and Nucleofill 25 use a higher 2.5% polynucleotide concentration for advanced bio-stimulation, targeting moderate to advanced signs of ageing, dullness, pigmentation, scars, and mild laxity. Nucleofill Eyes is formulated specifically for the delicate under-eye area.
Is Nucleofill a dermal filler?
No — Nucleofill is a regenerative skin booster designed to improve skin health and stimulate biological repair, rather than adding volume or facial contouring like a traditional dermal filler.
How many Nucleofill sessions are needed, and how long do results last?
Most protocols involve 2–4 treatments spaced a few weeks apart, with initial results often visible within a few weeks as collagen production builds progressively. Nucleofill is suitable for the face, neck, hands, and under-eye area.
Can I order Nucleofill in the UK as well as the EU?
Yes — ProAestheticSupply.eu ships Nucleofill to licensed clinics and practitioners across both the UK and EU. UK orders are fulfilled to MHRA-recognised standards, while EU orders carry full CE marking under EU MDR, giving clinics on either side of the Channel the same authenticity guarantee.
What should I order alongside Nucleofill?
Some practitioners layer Nucleofill with HA-based skin boosters such as Profhilo for immediate hydration alongside longer-term regeneration, or use TSK needles for precise injection. Browse our complete product catalogue, or check our FAQs for ordering and shipping information.
All Nucleofill products on ProAestheticSupply.eu are intended exclusively for use by licensed healthcare professionals and trained aesthetic practitioners, in accordance with applicable UK and EU regulations. Contact our customer support team if you need help selecting the right Nucleofill strength for a specific patient case.