Buy Mastelli Plinest Online | Original PN-HPT™ Polynucleotide for UK & EU Clinics
Plinest by Mastelli Aesthetic is the first and original polynucleotide (PN) injectable, introduced in 2005 by the Italian pharmaceutical company that pioneered the entire PN category. At ProAestheticSupply.eu, you can buy Plinest — along with related lines Newest and Triplest — with fast delivery across both the UK and EU, verified authenticity, and B2B pricing for licensed clinics.
Mastelli, founded in Sanremo in 1952, has over 70 years of research behind its proprietary PN-HPT™ (Polynucleotide High Purification Technology), which extracts highly purified DNA fragments from Italian trout — a source chosen for its high PDRN/PN concentration and exceptional compatibility with human skin. Plinest’s non-crosslinked formulation, containing 20mg/ml of polynucleotides, is designed for natural tissue integration with minimal risk of nodules or overcorrection, stimulating fibroblast activity to improve collagen production, tissue repair, and overall skin quality without adding volume.
Plinest is used to treat acne scars, dark circles, loss of elasticity, and general signs of ageing across the face, neck, and body. Pair it with our dermal fillers for structural correction alongside skin quality improvement, or browse the wider skin boosters category. Products supplied to UK clinics meet UK MHRA-recognised standards, while EU orders carry CE marking under EU MDR. Plinest is intended strictly for use by licensed healthcare and aesthetic professionals.
Shop Mastelli Plinest below — the original polynucleotide biostimulator, CE-certified and ISO-compliant, for collagen production, tissue repair, and skin regeneration. Shipped to clinics across the UK and EU. Browse our full skin boosters range for more options.
Buy Mastelli / Plinest
Buy Mastelli / Plinest
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Buy Mastelli / Plinest
Buy Mastelli / Plinest
Buy Bundles
Buy Bundles
Buy Bundles
Buy Bundles
A Complete Buying Guide to Mastelli Plinest
Plinest’s history traces back to the 1980s, when Dr. Oliviero Cattarini Mastelli and Dr. Maria Claudia Torlasco — the second generation of the Mastelli family — analysed the composition of the human placenta and identified PDRN/PN as its main active regenerative agent. Research into an alternative, more scalable source led Mastelli to Italian trout DNA, chosen for its high PDRN/PN content and compatibility with human tissue — resulting in Plinest, the first and original polynucleotide injectable.
What’s the difference between Plinest and Newest?
Plinest is a pure polynucleotide formulation without added hyaluronic acid. Newest combines Mastelli’s purified polynucleotides with hyaluronic acid, adding an immediate hydration effect alongside the longer-term regenerative action of PN — giving practitioners a choice depending on whether the priority is pure biostimulation or combined hydration and regeneration.
How is Plinest different from other polynucleotide products like Rejuran?
Plinest and Rejuran share the same core PDRN active ingredient derived from salmonid fish DNA, but are developed by different companies using different proprietary purification technologies — Mastelli’s PN-HPT™ in Italy versus PharmaResearch’s DOT™ in South Korea — resulting in distinct formulations with their own specific characteristics.
Is Plinest the same as a dermal filler or hyaluronic acid skin booster?
No — Plinest serves a fundamentally different purpose to a dermal filler, which adds volume and structure. Plinest instead improves the skin’s intrinsic quality and health at a cellular level without adding volume, making it complementary to rather than a replacement for volumizing treatments.
Can I order Plinest in the UK as well as the EU?
Yes — ProAestheticSupply.eu ships Mastelli Plinest to licensed clinics and practitioners across both the UK and EU. UK orders are fulfilled to MHRA-recognised standards, while EU orders carry full CE marking under EU MDR, giving clinics on either side of the Channel the same authenticity guarantee.
What should I order alongside Plinest?
Many practitioners combine Plinest with dermal fillers such as Neauvia for a combined structure-and-regeneration protocol, or use TSK needles for precise injection. Browse our complete product catalogue, or check our FAQs for ordering and shipping information.
All Mastelli Plinest products on ProAestheticSupply.eu are intended exclusively for use by licensed healthcare professionals and trained aesthetic practitioners, in accordance with applicable UK and EU regulations. Contact our customer support team if you need help selecting the right Mastelli product for a specific patient case.